Begin by selecting a map and difficulty level. Place your first monkey tower, such as the Dart Monkey, in a strategic location to cover the Bloon path. Upgrade towers using in-game currency earned by popping Bloons. Unlock heroes like Quincy or Silas to boost your defense. Experiment with tower synergies, such as combining the Alchemist’s buffs with high-damage towers like the Super Monkey, to handle tougher waves. Focus on upgrading towers at each level to maximize popping power and manage difficult Bloon types like Camo or Lead.